Research

In one study, distended veins improved considerably within only 60 minutes, and the effect was still prominent four hours later (Struckmann 1994). In addition, a Danish study showed that these amazing flavonoids were able to improve the elasticity of veins as well as help the capillaries by reducing permeability and leakage and support circulation (Struckmann 1999).
In Italy, a 42-day study was conducted with 40 people suffering from lower-limb circulation problems due to unstable blood sugar levels. Researchers measured the impact of hesperidin and diosmin on capillary filtration of albumin, a specific protein retention and filtration problem common among those with imbalanced blood sugar. Results showed that 55% of those taking the flavonoids achieved completely normal capillary filtration of albumin: a remarkable success in fewer than 45 days (Valensi 1996).
London researchers evaluated the effects of diosmin and hesperidin on 25 people who had lost normal elasticity in their leg veins. In just four weeks, those who received the nutrients demonstrated increased elasticity of their leg veins, healthy blood flow, and stronger venous structure (Ibegbuna 1997).
In yet another study, people at high risk of forming traveling blood clots were given hesperidin and diosmin both before and after undergoing major surgery. The injection of flavonoids dramatically reduced their risk compared with those who received a placebo (Tsimoyiannis 1996).

References
Ibegbuna, V. et al. (1997). “Venous elasticity after treatment with Daflon 500 mg.” Angiology; 48(1): 45-9.
Moore, D. (2002). “Fast facts: Blood clots.” March 18: www.drdonnica.com/display.asp?article=4671.
Struckmann, J.R. & Nicolaides, A.N. (1994). “Flavonoids: A review of the pharmacology and therapeutic efficacy of Daflon 500 mg in patients with chronic venous insufficiency and related disorders.” Angiology; 45(6): 419-28.
Struckmann, J.R. (1999). “Clinical efficacy of micronized purified flavonoid fraction: An overview.” Journal of Vascular Research; 36(Suppl 1): 37-41.
Tsimoyiannis, E.C. et al. (1996). “Low-molecular-weight heparins and Daflon for prevention of postoperative thromboembolism.” World Journal of Surgery; 20(8): 968-72.
Valensi, P.E. et al. (1996). “Effects of a purified micronized flavonoid fraction on capillary filtration in diabetic patients.” Diabetic Medicine; 13(10): 882-8.
*These statements have not been evaluated by the Food and Drug Administration(FDA). This product is not intended to diagnose, treat, cure or prevent any disease.